北京索萊寶科技
專注于生物學試劑及試劑盒領域
服務熱線：18101056239
專注于生物學試劑及試劑盒領域
服務熱線：18101056239
產品型號：K106589P
更新時間：2022-08-15
廠商性質：生產廠家
訪 問 量 ：923
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產品分類
Anti-ERK1/2 Polyclonal Antibody
| 英文名稱 | Anti-ERK1/2 Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | ERK;ERK-2;MAPK2;p38;p40;p41;p41mapk;p42-MAPK;P42MAPK;PRKM1;PRKM2 |
| 應用 | WB |
| 稀釋比例 | WB 1:500-2000. |
| 交叉反應 | Human Mouse Rat |
| 蛋白分子量 | 41kDa |
| Gene ID | 5594 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human ERK1/2 |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human ERK1/2 |
| Subcellular Locations | Cytoplasm Nucleus Cell membrane Cytoskeleton |
| Swiss Prot | P28482 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. |
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