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產(chǎn)品中心抗體Polyclonal AntibodyK106588PAnti-AIF Polyclonal Antibody
產(chǎn)品型號：K106588P
更新時間：2022-08-15
廠商性質(zhì)：生產(chǎn)廠家
訪 問 量 ：931
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產(chǎn)品分類
Anti-AIF Polyclonal Antibody
| 英文名稱 | Anti-AIF Polyclonal Antibody |
|---|---|
| 宿主 | Rabbit |
| 別名 | AIFM1;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8 |
| 應(yīng)用 | WB |
| 稀釋比例 | WB 1:500-2000. |
| 交叉反應(yīng) | Human Mouse Rat |
| 蛋白分子量 | 66kDa |
| Gene ID | 9131 |
| 保存 | Store at -20°C. Avoid freeze / thaw cycles. |
| 儲存液 | Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3. |
| 純化方法 | Affinity purification |
| 亞型 | IgG |
| 免疫原 | Recombinant protein of human AIF |
| 性狀 | 液體 |
| Public Immunogen Range | Recombinant protein of human AIF |
| Subcellular Locations | Cytoplasm |
| Swiss Prot | O95831 |
| 克隆類型 | Polyclonal Antibody |
| 背景資料 | Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. |
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